Longevity Genomics Integrative genomic resource to develop translational strategies to promote longevity

Publications

This page lists publications resulting from and related to this project.

Publications of this Project

  1. Backman T, Evans D, Girke T (2017) Large-scale Bioactivity Analysis of the Small-Molecule Assayed Proteome. PLoS ONE: 12, e0171413. PubMed
  2. Backman TW, Girke T (2016) systemPipeR: NGS workflow and report generation environment. BMC Bioinformatics: 17, 1-8. PubMed
  3. Backman TW, Girke T (2016) bioassayR: Cross-Target Analysis of Small Molecule Bioactivity. J Chem Inf Model: Epub ahead of print. PubMed

[ PubMed Search ]

  1. Brion M-JA, Shakhbazov K, Visscher PM (2013) Calculating statistical power in Mendelian randomization studies. Int J Epidemiol 42: 1497–1501 PubMed
  2. Sheehan NA, Didelez V, Burton PR, Tobin MD (2008) Mendelian randomisation and causal inference in observational epidemiology. PLoS Med 5: e177 PubMed
  3. Smith GD, Ebrahim S (2004) Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol 33: 30–42 PubMed
  4. Deelen J, Beekman M, Uh HW, Broer L, Ayers KL, et al. (2014) Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. Hum Mol Genet, 23:4420-32. PubMed
  5. Broer, L, Buchman, AS, Deelen, J, Evans, DS, Faul, JD, et al. (2014). GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy. J Gerontol A Biol Sci Med Sci, 70(1):110-118. PubMed
  6. Fortney K, Dobriban E, Garagnani P, Pirazzini C, Monti D, Mari D, Atzmon G, Barzilai N, Franceschi C, Owen AB, et al (2015) Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity. PLoS Genet 11: e1005728 PubMed
  7. Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016) Human Longevity is Influenced by Many Genetic Variants: Evidence from 75,000 UK Biobank Participants. bioRxiv 038430 biorxiv
  8. Sood S, Gallagher I, Lunnon K, Rullman E, Keohane A, Crossland H, Phillips B, Cederholm T, Jensen T, van Loon L, et al (2015) A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status. Genome Biology 16: 185 PubMed
  9. Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, et al (2015) The transcriptional landscape of age in human peripheral blood. Nat Commun 6: 8570 PubMed
  10. Wagner AH, Coffman AC, Ainscough BJ, Spies NC, Skidmore ZL, Campbell KM, Krysiak K, Pan D, McMichael JF, Eldred JM, et al (2016) DGIdb 2.0: mining clinically relevant drug-gene interactions. Nucleic Acids Res 44: D1036–44 PubMed
  11. Wagner AH, Coffman AC, Ainscough BJ, Spies NC, Skidmore ZL, Campbell KM, Krysiak K, Pan D, McMichael JF, Eldred JM, et al (2016) DGIdb 2.0: mining clinically relevant drug-gene interactions. Nucleic Acids Res 44: D1036–44
  12. Hu G, Agarwal P (2009) Human disease-drug network based on genomic expression profiles. PLoS One 4: e6536 PubMed
  13. Huang H, Nguyen T, Ibrahim S, Shantharam S, Yue Z, Chen JY (2015) DMAP: a connectivity map database to enable identification of novel drug repositioning candidates. BMC Bioinformatics 16 Suppl 13: S4 PubMed
  14. Marioni R, Shah S, McRae A, Chen B, Colicino E, Harris S, Gibson J, Henders A, Redmond P, Cox S, et al (2015) DNA methylation age of blood predicts all-cause mortality in later life. Genome Biology 16: 25 PubMed
  15. De Haes W, Frooninckx L, Van Assche R, Smolders A, Depuydt G, Billen J, Braeckman BP, Schoofs L, Temmerman L (2014) Metformin promotes lifespan through mitohormesis via the peroxiredoxin PRDX-2. Proc Natl Acad Sci U S A 111: E2501–9 PubMed
  16. Leiser SF, Miller H, Rossner R, Fletcher M, Leonard A, Primitivo M, Rintala N, Ramos FJ, Miller DL, Kaeberlein M (2015) Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span. Science 350: 1375–1378 PubMed
  17. Hannum G, Guinney J, Zhao L, Zhang L, Hughes G, Sadda S, Klotzle B, Bibikova M, Fan J-B, Gao Y, et al (2013) Genome-wide methylation profiles reveal quantitative views of human aging rates. Mol Cell 49: 359–367 PubMed
  18. Horvath S (2013) DNA methylation age of human tissues and cell types. Genome Biol 14: R115 PubMed
  19. Lamb J, Crawford ED, Peck D, Modell JW, Blat IC, Wrobel MJ, Lerner J, Brunet JP, Subramanian A, Ross KN, Reich M, Hieronymus H, Wei G, Armstrong SA, Haggarty SJ, Clemons PA, Wei R, Carr SA, Lander ES, Golub TR (2006) The Connectivity Map: using gene-expression signatures to connect small molecules, genes, and disease. Science 313(5795):1929-35. Pubmed


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