Publications

Publications of this Project

  1. McCorrison J, Girke T, Goetz LH, Miller RA, Schork NJ. Genetic Support for Longevity-Enhancing Drug Targets: Issues, Preliminary Data and Future Directions. J. Gerontology (in press).
  2. Deelen J, Evans DS, Arking DE, Tesi N, Nygaard M, Liu X, Wojczynski MK, Biggs ML, van der Spek A, Atzmon G, et al (2019) A meta-analysis of genome-wide association studies identifies multiple longevity genes. Nat Commun 10: 3669. PubMed
  3. Shah P, Kendall F, Khozin S, Goosen R, Hu J, Laramie J, Ringel M, Schork N. Artificial intelligence and machine learning in clinical development: a translational perspective. NPJ Digit Med. 2019 Jul 26;2:69. doi: 10.1038/s41746-019-0148-3. eCollection 2019. Review. PMID: 31372505 

  4. Schork NJ. Artificial Intelligence and Personalized Medicine. Cancer Treat Res. 2019;178:265-283. doi: 10.1007/978-3-030-16391-4_11. PMID: 31209850

  5. Schork NJ, Raghavachari N; Workshop Speakers and Participants. Report: NIA workshop on translating genetic variants associated with longevity into drug targets. Geroscience. 2018 Dec;40(5-6):523-538. doi: 10.1007/s11357-018-0046-7. Epub 2018 Oct 29. PMID: 30374935 

  6. Schork AJ, Schork MA, Schork NJ. Genetic risks and clinical rewards. Nat Genet. 2018 Sep;50(9):1210-1211. doi: 10.1038/s41588-018-0213-x. No abstract available. PMID: 30158681 

  7. Rangan AV, McGrouther CC, Kelsoe J, Schork N, Stahl E, Zhu Q, Krishnan A, Yao V, Troyanskaya O, Bilaloglu S, Raghavan P, Bergen S, Jureus A, Landen M; Bipolar Disorders Working Group of the Psychiatric Genomics Consortium. A loop-counting method for covariate-corrected low-rank biclustering of gene-expression and genome-wide association study data. PLoS Comput Biol. 2018 May 14;14(5):e1006105. doi: 10.1371/journal.pcbi.1006105. eCollection 2018 May. PMID: 29758032

  8. Choi Y, Chan AP, Kirkness E, Telenti A, Schork NJ. Comparison of phasing strategies for whole human genomes. PLoS Genet. 2018 Apr 5;14(4):e1007308. doi: 10.1371/journal.pgen.1007308. eCollection 2018 Apr. PMID: 29621242 

  9. Long T, Hicks M, Yu HC, Biggs WH, Kirkness EF, Menni C, Zierer J, Small KS, Mangino M, Messier H, Brewerton S, Turpaz Y, Perkins BA, Evans AM, Miller LA, Guo L, Caskey CT, Schork NJ, Garner C, Spector TD, Venter JC, Telenti A. Whole-genome sequencing identifies common-to-rare variants associated with human blood metabolites. Nat Genet. 2017 Apr;49(4):568-578. doi: 10.1038/ng.3809. Epub 2017 Mar 6. PMID: 28263315

  10. Ding KF, Finlay D, Yin H, Hendricks WPD, Sereduk C, Kiefer J, Sekulic A, LoRusso PM, Vuori K, Trent JM, Schork NJ. Analysis of variability in high throughput screening data: applications to melanoma cell lines and drug responses. Oncotarget. 2017 Apr 25;8(17):27786-27799. doi: 10.18632/oncotarget.15347. PMID: 28212541 

  11. Ding KF, Petricoin EF, Finlay D, Yin H, Hendricks WPD, Sereduk C, Kiefer J, Sekulic A, LoRusso PM, Vuori K, Trent JM, Schork NJ. Nonlinear mixed effects dose response modeling in high throughput drug screens: application to melanoma cell line analysis. Oncotarget. 2017 Dec 15;9(4):5044-5057. doi: 10.18632/oncotarget.23495. eCollection 2018 Jan 12. PMID: 29435161

  12. Zillikens MC, Demissie S, Hsu Y-H, Yerges-Armstrong LM, Chou W-C, Stolk L, Livshits G, Broer L, Johnson T, Koller DL, et al (2017) Large meta-analysis of genome-wide association studies identifies five loci for lean body mass. Nat Commun 8: 80. PubMed
  13. Backman T, Evans D, Girke T (2017) Large-scale Bioactivity Analysis of the Small-Molecule Assayed Proteome. PLoS ONE: 12, e0171413. PubMed
  14. Backman TW, Girke T (2016) systemPipeR: NGS workflow and report generation environment. BMC Bioinformatics: 17, 1-8. PubMed
  15. Backman TW, Girke T (2016) bioassayR: Cross-Target Analysis of Small Molecule Bioactivity. J Chem Inf Model: Epub ahead of print. PubMed

PubMed Search ]

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  2. Brion M-JA, Shakhbazov K, Visscher PM (2013) Calculating statistical power in Mendelian randomization studies. Int J Epidemiol 42: 1497–1501 PubMed
  3. Sheehan NA, Didelez V, Burton PR, Tobin MD (2008) Mendelian randomisation and causal inference in observational epidemiology. PLoS Med 5: e177 PubMed
  4. Smith GD, Ebrahim S (2004) Mendelian randomization: prospects, potentials, and limitations. Int J Epidemiol 33: 30–42 PubMed
  5. Deelen J, Beekman M, Uh HW, Broer L, Ayers KL, et al. (2014) Genome-wide association meta-analysis of human longevity identifies a novel locus conferring survival beyond 90 years of age. Hum Mol Genet, 23:4420-32. PubMed
  6. Broer, L, Buchman, AS, Deelen, J, Evans, DS, Faul, JD, et al. (2014). GWAS of Longevity in CHARGE Consortium Confirms APOE and FOXO3 Candidacy. J Gerontol A Biol Sci Med Sci, 70(1):110-118. PubMed
  7. Fortney K, Dobriban E, Garagnani P, Pirazzini C, Monti D, Mari D, Atzmon G, Barzilai N, Franceschi C, Owen AB, et al (2015) Genome-Wide Scan Informed by Age-Related Disease Identifies Loci for Exceptional Human Longevity. PLoS Genet 11: e1005728 PubMed
  8. Pilling LC, Atkins JL, Bowman K, Jones SE, Tyrrell J, Beaumont RN, Ruth KS, Tuke MA, Yaghootkar H, Wood AR, et al (2016) Human Longevity is Influenced by Many Genetic Variants: Evidence from 75,000 UK Biobank Participants. bioRxiv 038430biorxiv
  9. Sood S, Gallagher I, Lunnon K, Rullman E, Keohane A, Crossland H, Phillips B, Cederholm T, Jensen T, van Loon L, et al (2015) A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status. Genome Biology 16: 185 PubMed
  10. Peters MJ, Joehanes R, Pilling LC, Schurmann C, Conneely KN, Powell J, Reinmaa E, Sutphin GL, Zhernakova A, Schramm K, et al (2015) The transcriptional landscape of age in human peripheral blood. Nat Commun 6: 8570 PubMed
  11. Wagner AH, Coffman AC, Ainscough BJ, Spies NC, Skidmore ZL, Campbell KM, Krysiak K, Pan D, McMichael JF, Eldred JM, et al (2016) DGIdb 2.0: mining clinically relevant drug-gene interactions. Nucleic Acids Res 44: D1036–44 PubMed
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  16. Leiser SF, Miller H, Rossner R, Fletcher M, Leonard A, Primitivo M, Rintala N, Ramos FJ, Miller DL, Kaeberlein M (2015) Cell nonautonomous activation of flavin-containing monooxygenase promotes longevity and health span. Science 350: 1375–1378 PubMed
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